TPX-0046 is a novel and potent RET/SRC inhibitor for RET-driven cancers
نویسندگان
چکیده
منابع مشابه
Ponatinib is a potent inhibitor of wild-type and drug-resistant gatekeeper mutant RET kinase.
RET kinase is aberrantly activated in thyroid cancers and in rare cases of lung and colon cancer, and has been validated as a molecular target in these tumors. Vandetanib was recently approved for the treatment of medullary thyroid cancer. However, vandetanib is ineffective in vitro against RET mutants carrying bulky aminoacids at position 804, the gatekeeper residue, similarly to drug-resistan...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2019
ISSN: 0923-7534
DOI: 10.1093/annonc/mdz244.068